How to Apply Tretinoin Cream: A Guide to Demystifying Its Use

Tretinoin, often known by its brand name Retin-A, is a dermatologist-favored powerhouse for combatting skin aging. But navigating its application and layering with other skincare products can be confusing. Fear not! This comprehensive guide, informed by my expertise as a dermatologist with 35+ years of experience, will unlock the secrets to the transformative skincare potential that helps your skin tolerate tretinoin and fend off wrinkles.

Let’s demystify tretinoin once and for all. You will learn key dermatologist tested practical tips about how to apply tretinoin and how to layer it – do you put it on before or after a moisturizer, and how to use it with other skincare products. Then we’ll break down how to create your optimal tretinoin skin care routine, set up your nighttime tretinoin regimen, how to use it based on your complexion, look at alternatives, and the best products to maximize the age defying benefits of using tretinoin. I even included some educational content beyond the basics to help you better understand tretinoin and its use.

Imagine… soothed skin, minimized pores, and a healthy, radiant, youthful glowing skin.

• Tretinoin is a prescription medication used for acne, aging, and pigmentation. How you use this medicine is ultimately the responsibility of your prescribing doctor. The information presented here discusses how I have used tretinoin in my practice. Please discuss these approaches with your prescribing physician.
• It can cause irritation, dryness, and sun sensitivity especially in the beginning months of introducing it into your skincare routine.
• Tretinoin is not a moisturizer. Although it contains a moisturizing base, tretinoin can be irritating on damp skin. Always prioritize a dedicated moisturizer for optimal hydration.
• All of the tretinoin benefits have excellent scientific proof.
• Retinol, just like tretinoin, is a retinoid. Retinol is a well-known and less irritating non-prescription option similar to tretinoin. Medical-grade retinol products share the same proven benefits as tretinoin when used at the highest available retinol concentration.

Every dermatologist I know considers retinoids the single most important skin care ingredient, along with sunscreen, to fight skin aging. In fact, we all use a retinoid in our personal skin care routines.

Apply retinoids, like tretinoin and retinol, at night. Retinoids, like tretinoin and retinol are deactivated when exposed to light so it’s best to put them on right before you turn out your light to go to sleep.

Always Apply It to Dry Skin

Dry skin is key. Yes, tretinoin is in a moisturizing base, but because it causes irritation if applied to damp skin, it can’t be your moisturizer! This is not true of retinol but because of these particular tretinoin ‘issues’, I share the steps of my nighttime skin care regimen for tretinoin users further below.

Do You Apply Tretinoin Before or After a Moisturizer

Moisturizer first, wait, then tretinoin: Apply your moisturizer, wait at least 15 minutes to allow it to absorb, and then proceed with tretinoin to avoid irritation. Then it’s ‘lights out’. Follow the tretinoin skincare routine steps below in this guide to build a regimen that will work for your complexion.

How Long Should You Wait to Apply a Moisturizer

Some individuals, especially those with sensitive skin, benefit from a 15 to 30 minute wait after cleansing before applying tretinoin. The 15+ minute wait allows the skin barrier to recover and minimizes irritation. This helps reduce the risk of tretinoin induced retinoid dermatitis, a common issue for many tretinoin users.

Additional Application Tips

• Wash your face and hands before applying any products.
• Start slow: Begin with applying tretinoin 2-3 nights per week, gradually increasing frequency as tolerated. This approach is also good to follow if you are introducing retinol instead of tretinoin.
• Use only a pea-sized amount for your face. More can be irritating. Dot it on key areas and spread evenly. If you are using it on your neck and chest, each gets another pea-size dollop. Know that tretinoin can irritate neck and chest skin so consult your prescribing physician.
• Use sunscreen daily. Tretinoin increases sun sensitivity.
• Listen to your skin. Adjust your routine based on any irritation or dryness.
• Consult your dermatologist for professional guidance on personalized advice and concerns.

The secret to creating a powerful and complexion transforming skin care routine is to build what I call a Complete Skin Care Routine. It gives the skin everything it needs in the 4 essential steps: Cleanse, Correct, Hydrate, Protect.

Here is your guide to building a skincare routine with the steps to successfully layer tretinoin (or retinol). Look for the section where we discuss specific considerations and options you should follow based on your complexion.

How to Layer Tretinoin with Other Products

Application timing and product combinations can make or break the results. Often you won’t know things aren’t working for weeks or months. It’s why I’m so specific about the products and tretinoin skin care regimens I recommend.

I cover each of these key steps in more detail further below:

1. Choose the right products to use and layer with tretinoin
2. Follow the nighttime skincare routine below
3. Customize your routine based on my recommendations in the complexion based layering options section of this guide

1. Complete Facial Skin Care Kit: Ideal for layering with tretinoin.
• It comes with a gentle facial cleanser, moisturizer, green tea antioxidant therapy, and matte tinted sunscreen.
  
  
2. Ageless Rejuvenation Skin Care Kit: Perfect for alternating tretinoin with a gentler option, retinol.
• This kit includes all the products from the Complete Facial Skin Care Kit, plus two additional powerful anti-aging creams:
• A Retinol Night Cream that offers similar benefits to tretinoin but with less irritation, allowing you to alternate with tretinoin or use it in its place when tretinoin is too strong. It also includes Glycolic Acid Cream for wrinkle and sunspots control.
  

I use all of these products for my own routine to keep my skin as healthy and glowing as I can. I alternate my Retinol Cream with tretinoin because it is easier to use.

See the below sections on complexion based routine options and more on alternating tretinoin with retinol.

Wash your face with warm water and the gentle pH  balanced Extremely Gentle Cleanser, which  cleans skin well without irritating or over-drying.

Rinse really well to remove makeup, dirt, pollution and product residue so that your bedtime products will penetrate well while you sleep.

2. Correct + Hydrate

The core steps when using tretinoin are listed below, however please see the layering options explained under these steps to build your specific steps:

1. Ensure your skin is completely dry
2. Apply Green Tea Antioxidant Skin Therapy
3. Follow with Daily Moisturizing Face Cream
4. Wait at least 15 or 30 minutes
5. Apply tretinoin
6. Turn off lights and go to sleep

Complexion Based Layering Options

Customized routines understand the variations based on individual needs and tolerance.

There are 4 bedtime layering options for the Correct and Hydrate steps in a skincare routine depending on your unique complexion, products used, and skin’s tolerance because glycolic acid and retinoids can cause irritation.

Choose the option that best suits your skin’s tolerance:

1. When using Tretinoin: Apply Green Tea Cream, follow with Daily Face Cream, wait 15+ minutes or more, then apply tretinoin
2. When using Retinol: Apply Retinol Anti-Wrinkle Night Cream directly after cleansing, followed by Daily Moisturizing Face Cream
3. If you can tolerate Retinol + Glycolic Acid simultaneously: Apply Retinol Night Cream, followed by Glycolic Acid Face Cream
4. Complexions that can tolerate Tretinoin + Glycolic Acid: Apply Green Tea Cream, followed by Glycolic Acid Cream, wait 15+ minutes, then apply tretinoin (requires your doctor’s approval)

In building a routine I also use common sense and the principle of applying water-based (thin) products first followed by oil/occlusive (thicker and more viscous) products on top. This will help product ingredients diffuse into the skin.

Tretinoin is a retinoid. Retinol is in the same family, also has good scientific evidence for the same skin benefits, and is the best retinoid that is available without prescription.

• Retinol is converted to retinoic acid in your skin (which is what tretinoin is). 
• Retinol is less irritating than tretinoin.
• The Retinol Cream contains the same high concentration green tea antioxidants and so it is a two-fer. This means that when using the Retinol Cream, there is no need to apply Green Tea.
• Conversely, some people with really tolerant complexions may combine Retinol (or even tretinoin) and Glycolic Acid Cream together.

Your skincare routine is important for fighting skin aging. Tretinoin and retinol are powerhouse ingredients with proven results. Training your skin to tolerate one or both of these retinoids is worth the effort!

Your Kit for Alternating Tretinoin and Retinol

I created my Ageless Rejuvenation Skin Care Kit to help give people confidence with layering tretinoin into an even more powerful state-of-the-art anti-aging skin care routine. It includes my Retinol Night Cream to alternate with tretinoin or to use in place of tretinoin. It also includes my Glycolic Acid Cream and Matte Tinted Sunscreen, SPF 50. 

Explore Further

Learn more about how retinol works, its benefits, and how to use it in my detailed article:

What is Retinol and How Does it Work for Your Skin?

For more information on how I coach my patients on the use of tretinoin cream you may want to read my post:

How to Correctly Use Retin A (tretinoin) for Acne and Anti-Aging Skin Care

Dear Dr. Bailey, Thank you so much for your very informative blog. I have learned a lot from reading your articles, but I am still a little confused with regards to when to apply all the products. Do I understand correctly that if I put on the Green Tea Antioxidant Cream right after washing my face then I can layer either with vitamin C, glycolic acid or tretinoin cream? And then moisturizer on top of this? Do I need to wait before layering one skin care product or can one go on top of another right after applying? Say if I use the Green Tea Cream, then prescription tretinoin and then moisturizer, will this not dilute the effect of the tretinoin? Alis

Here is another reader’s question I received about how to layer products in a skin care routine with tretinoin:

Hi Dr. Bailey, I wanted to ask if the Green Tea Antioxidant Skin Therapy can be used before tretinoin and what the benefit is? I’m also wondering if a moisturizer can be applied either before or after using tretinoin? Thanks! Robin

The answer is actually part of the ‘fine points’ of a powerful anti-aging skin care routine. The reason people are often confused is that, honestly speaking, no studies have really been done regarding individual product applications. Plus, opinions even among dermatologists will vary. This is why you get conflicting recommendations.

I created this guide to answer questions like the ones here, for everyone. Find the answers you are looking for:

Can You Use Retinol and Tretinoin Together

Yes, retinol and tretinoin offer the same benefits and can be alternated for convenience. Retinol is definitely more convenient and easier to use and is less irritating to sensitive skin than tretinoin. You also don’t need to wait 15 or more minutes after washing before applying retinol to help prevent irritation. I personally alternate these 2 retinoids; I apply tretinoin as often as possible and use retinol when my skin is feeling sensitive or I don’t want to wait before completing my bedtime routine. I like to say, “you always want to sleep with a retinoid!”. Pick which one based on your skin’s sensitivity and whether you can wait 15 minutes before falling asleep.

See my recommendations above in the Complexion Based Layering Options and Alternating Tretinoin with Retinol section of this guide.

Your Kit for Alternating Tretinoin and Retinol: The Ageless Rejuvenation Skin Care Kit offers a gentler alternative for nights when tretinoin might be too strong, or to completely replace it. The kit includes the Retinol Night Cream, boasting similar benefits to tretinoin but with less irritation. Additionally, the kit includes Glycolic Acid Cream to target wrinkles and sunspots, making it a powerful anti-aging solution.

Explore further: What is Retinol and What are Its Benefits for Your Skin

Can Tretinoin and Vitamin C Be Used Together

Yes, the best way to combine vitamin C and tretinoin in your skincare routine is to use tretinoin at night and vitamin C during the day. As mentioned above, retinoids, such as tretinoin and retinol, are inactivated by exposure to light. They are best used as nightime products. Vitamin C is a powerful antioxidant that you want present on your skin during the day to help reduce the risk of free radical skin damage. Apply a vitamin C serum under sunscreen during the day, or use a sunscreen that includes vitamin C such as my Sheer Strength Pure Physical Matte Tinted SPF 50 Sunscreen, and get the best of these age-fighting products.

However, it is difficult to formulate vitamin C serums that are stable and effective.

In my observation in treating thousands of patients, green tea polyphenols are a much better alternative to vitamin C for antioxidant skin care. Green tea polyphenols are also less irritating to the skin than vitamin C.  I recommend my Green Tea Antioxidant Skin Therapy for high concentration antioxidant skin care to help reduce free radical skin damage. I prefer retinoids and glycolic acid to brighten the complexion and fight the signs of skin aging such as wrinkles, crepey skin, age spots, and pigment skin problems.

Learn more in my article where I go into details about vitamin C:
Using Vitamin C: How to Choose the Best Anti-aging Skin Care Products

Green Tea’s Antioxidant Shield

I recommend a nightly application of Green Tea Antioxidant Skin Therapy before tretinoin to get all the antioxidant and anti-inflammatory effects to help your skin tolerate tretinoin and fend off skin aging. It also helps soothe irritation and bolster your skin’s defenses against aging by loading the skin’s antioxidant reserve with the best antioxidant for skin care (EGCG-3 polyphenols).

My Retinol Night Cream contains the same patented high concentration of ECGC green tea polyphenol antioxidant. It thus combines retinoid skin benefits with green tea benefits, and does not require a prescription. It is much less irritating than tretinoin and can be applied in place of the Green Tea Antioxidant Skin Therapy. Moisturizer can be layered immediately, and you can then turn off the lights and go to bed!

Green Tea Antioxidant Skin Therapy is simply the best antioxidant green tea skin care product made in my opinion. It contains a patented form of highly concentrated green tea polyphenol (ECGC type) antioxidants. – Dr. Bailey

Explore further: Benefits of Green Tea for Skin

All Tretinoin Benefits Have Excellent Scientific Proof

• The mechanism of how tretinoin stimulates collagen formation to reverse wrinkles is fully worked out.
• The different ways that it helps to reduce unwanted pigment problems such as melasma and sun spots have been identified.
• The way that it works to alter skin structure to brighten the complexion and give it a dewy and youthful appearance is also well understood.

• Complete Facial Skin Care Kit: This kit provides the essential companions for tretinoin layering. Importantly, it incorporates Green Tea Cream, which I have found essential to reduce the risk of tretinoin skin irritation. I have selected a non-drying pH balanced cleanser, deeply hydrating moisturizer and non-irritating sunscreen, all of which help to enable tretinoin success.
• Ageless Rejuvenation Skin Care Kit: Want to alternate tretinoin with a gentler option? This kit includes everything the Complete Facial Kit does, plus my Retinol Night Cream offering less irritation so you can alternate or replace tretinoin. And, it includes Glycolic Acid Cream to target wrinkles and sunspots, making it a powerful anti-aging solution.

Disclaimer: Please realize that availing yourself of the opportunity to submit and receive answers to your questions from Dr. Bailey does not confer a doctor/patient relationship with Dr. Bailey. The information provided by Dr. Bailey is general health information inspired by your question. It should not be a substitute for obtaining medical advice from your physician and is not intended to diagnose or treat any specific medical problem (and is not an extension of the care Dr. Bailey has provided in her office for existing patients of her practice). Never ignore your own doctor’s advice because of something you read here; this information is for general informational purpose only.