Oral Health

Quebec company’s papain-based gel approved for anesthesia-free caries removal


The papain enzyme in the gel breaks down decayed proteins, softening infected dentin.
The papain enzyme in the gel breaks down decayed proteins, softening infected dentin. (iStock)

Quebec-based Oral Science has announced the approval of its papain-based enzyme gel, Papacárie Duo, for minimally invasive and anesthesia-free caries removal.

Papacárie Duo, which uses an innovative chemomechanical process, has received Health Canada approval (NPN 80129669), offering an alternative to traditional drilling techniques.

How it works

Papain works by selectively breaking down denatured collagen found in decayed dentin, softening the carious tissue while leaving healthy tooth structure intact. This enzyme-driven method significantly reduces the need for anesthesia and minimizes patient discomfort, making it a valuable option for those seeking less invasive dental procedures.

Key benefits of papain-based caries removal:

  • Selective Proteolysis: Papain targets damaged proteins in decayed dentin, leaving healthy tissue unaffected.
  • Non-Invasive Removal: The softened decayed material can be gently removed using hand instruments, eliminating the need for rotary drills.
  • Patient-Friendly: This painless procedure is ideal for pediatric, geriatric, and special-care patients.





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